both before disease cube regain

Beholder Zombie

Monsters Monster Manual

", "rollAction":"Enervation Ray", "rollDamageType":"Necrotic"} Necrotic damage, and the target has the Poisoned condition until the end of its next turn. While Poisoned, the target can’t regain Hit

", "rollDamageType":"Force"} Force damage. If the target is a nonmagical object or a creation of magical force, a 10-foot Cube of it disintegrates into dust. Success: Half damage. Failure or Success: If the target is a creature and this damage reduces it to 0 Hit Points, it disintegrates into dust. Poison

Death Tyrant

Monsters Monster Manual

", "rollAction":"Failure", "rollDamageType":"Poison"} Poison damage, and the target has the Poisoned condition until the end of its next turn. While Poisoned, the target can’t regain Hit Points

", "rollAction":"Disintegration Ray", "rollDamageType":"Force"} Force damage. If the target is a nonmagical object or a creation of magical force, a 10-foot Cube of it disintegrates into dust. Success

Beholder

Monsters Monster Manual

":"Enervation Ray", "rollDamageType":"Poison"} Poison damage, and the target has the Poisoned condition until the end of its next turn. While Poisoned, the target can’t regain Hit Points. Success: Half

":"Disintegration Ray", "rollDamageType":"Force"} Force damage. If the target is a nonmagical object or a creation of magical force, a 10- foot Cube of it disintegrates into dust. Success: Half damage. Failure

Mark of Detection

Feats Eberron: Forge of the Artificer

. Magical Detection. You always have the Detect Magic and Detect Poison and Disease spells prepared. You can cast each spell once without a spell slot, and you regain the ability to cast it in that way when

Diseased Giant Rat Legacy

Monsters Basic Rules (2014)

contract a disease. Until the disease is cured, the target can't regain hit points except by magical means, and the target's hit point maximum decreases by 3 (1d6);{"diceNotation":"1d6","rollType

":"roll","rollAction":"Bite"} every 24 hours. If the target's hit point maximum drops to 0 as a result of this disease, the target dies.Some giant rats carry vile diseases that they spread with their bites.

Swarm of Rats (Diseased Variant)

Monsters Tales from the Yawning Portal

saving throw or contract a disease. Until the disease is cured, the target can't regain hit points except by magical means, and the target's hit point maximum decreases by 3 (1d6);{"diceNotation":"1d6

large enough for a Tiny rat. The swarm can't regain hit points or gain temporary hit points.Bite. Melee Weapon Attack: +2;{"diceNotation":"1d20+2","rollType":"to hit","rollAction":"Bite"} to hit, reach

Guthash

Monsters Tales from the Yawning Portal

contract a disease. Until the disease is cured, the target can't regain hit points except by magical means, and the target's hit point maximum decreases by 3 (1d6);{"diceNotation":"1d6","rollType

":"roll","rollAction":"Bite"} every 24 hours. If the target's hit point maximum drops to 0 as a result of this disease, the target dies.A monstrously swollen female diseased giant rat [6 feet long] that

Blue Slaad Legacy

Monsters Monster Manual (2014)

damage. If the target is a humanoid, it must succeed on a DC 15 Constitution saving throw or be infected with a disease called chaos phage. While infected, the target can’t regain hit points, and

its hit point maximum is reduced by 10 (3d6);{"diceNotation":"3d6","rollType":"roll","rollAction":"Claw"} every 24 hours. If the disease reduces the target’s hit point maximum to 0, the target

Swarm of Maggots

Monsters Van Richten’s Guide to Ravenloft

Swarm. The swarm can occupy another creature’s space and vice versa, and the swarm can move through any opening large enough for a Tiny maggot. The swarm can’t regain hit points or gain

","rollDamageType":"piercing"} piercing damage if the swarm has half of its hit points or fewer. A creature damaged by the swarm must succeed on a DC 12 Constitution saving throw or contract a disease

Oddlewin

Monsters The Book of Many Things

saving throw or have the charmed condition until the end of the creature’s next turn. The creature must use its action praising Oddlewin. Oddlewin can’t regain hit points, including

conjures magical cards that slash at the air in a 5-foot cube within 60 feet of Oddlewin until the start of Oddlewin’s next turn. A creature that starts its turn in the cube or that enters that

Tlacatecolo

Monsters Journeys through the Radiant Citadel

Winds (Fiend Form Only; Recharge 5–6;{"diceNotation":"1d6","rollType":"recharge","rollAction":"Plague Winds"}). The tlacatecolo emits a chilling, disease-ridden wind in a 60-foot line that is 10 feet

damage and become poisoned. While poisoned in this way, the creature can’t regain hit points. At the end of every hour, the creature must succeed on a DC 13 Constitution saving throw or gain 1

Swarm of Rot Grubs Legacy

Monsters Volo's Guide to Monsters

Swarm. The swarm can occupy another creature's space and vice versa, and the swarm can move through any opening large enough for a Tiny maggot. The swarm can't regain hit points or gain temporary hit

grubs. After this time, these rot grubs are too far under the skin to be burned. If a target infested by rot grubs ends its turn with 0 hit points, it dies as the rot grubs burrow into its heart and kill it. Any effect that cures disease kills all rot grubs infesting the target.Piercing, Slashing

Aboleth Legacy

Monsters Basic Rules (2014)

skin becomes translucent and slimy, the creature can’t regain hit points unless it is underwater, and the disease can be removed only by heal or another disease-curing spell of 6th level or higher

succeed on a DC 14 Constitution saving throw or become diseased. The disease has no effect for 1 minute and can be removed by any magic that cures disease. After 1 minute, the diseased creature’s

Blue Slaad (control gem variant) Legacy

Monsters Monster Manual (2014)

phage. While infected, the target can't regain hit points, and its hit point maximum is reduced by 10 (3d6);{"diceNotation":"3d6","rollType":"roll","rollAction":"Claw"} every 24 hours. If the disease

":"damage","rollAction":"Claw","rollDamageType":"slashing"} slashing damage. If the target is a humanoid, it must succeed on a DC 15 Constitution saving throw or be infected with a disease called chaos

Instant Fortress Legacy

Magic Items Basic Rules (2014)

You can use an action to place this 1-inch metal cube on the ground and speak its command word. The cube rapidly grows into a fortress that remains until you use an action to speak the command word

. Only a wish spell can repair the fortress (this use of the spell counts as replicating a spell of 8th level or lower). Each casting of wish causes the roof, the door, or one wall to regain 50 hit points.

Reduced-threat Aboleth

Monsters Tales from the Yawning Portal

by any magic that cures disease. After 1 minute, the diseased creature's skin becomes translucent and slimy, the creature can't regain hit points unless it is underwater, and the disease can be removed

","rollDamageType":"bludgeoning"} bludgeoning damage. If the target is a creature, it must succeed on a DC 12 Constitution saving throw or become diseased. The disease has no effect for 1 minute and can be removed

Daern's Instant Fortress Legacy

Magic Items Dungeon Master’s Guide (2014)

You can use an action to place this 1-inch metal cube on the ground and speak its command word. The cube rapidly grows into a fortress that remains until you use an action to speak the command word

. Only a wish spell can repair the fortress (this use of the spell counts as replicating a spell of 8th level or lower). Each casting of wish causes the roof, the door, or one wall to regain 50 hit points.

Venom Troll

Monsters Mordenkainen Presents: Monsters of the Multiverse

15-foot cube. The troll takes 7 (2d6);{"diceNotation":"2d6", "rollType":"damage", "rollAction":"Venom Spray", "rollDamageType":"slashing"} slashing damage, which can’t be reduced in any way. Each

;rot trolls, spirit troll;spirit trolls, and venom trolls that follow are especially likely to arise when trolls regenerate in the presence of magical emanations, planar energy, disease, or death on a

Oinoloth

Monsters Mordenkainen Presents: Monsters of the Multiverse

addition, the oinoloth can end one disease on the target or remove one of the following conditions from it: blinded, deafened, paralyzed, or poisoned. The target then gains 1 level of exhaustion, and

creature is immune to the oinoloth’s Bringer of Plagues for the next 24 hours. The poisoned creature can’t regain hit points. After every 24 hours that elapse, the poisoned creature can

Oinoloth Legacy

Monsters Mordenkainen’s Tome of Foes

next 24 hours. On a failed save, the creature takes 14 (4d6);{"diceNotation":"4d6","rollType":"damage","rollDamageType":"necrotic"} necrotic damage and is poisoned. The poisoned creature can't regain

","rollType":"recharge","rollAction":"Corrupted Healing"}. The oinoloth touches one willing creature within 5 feet of it. The target regains all its hit points. In addition, the oinoloth can end one disease on

Death Tyrant Legacy

Monsters Monster Manual (2014)

and whether the cone is active. Any creature in that area can’t regain hit points. Any humanoid that dies there becomes a zombie under the tyrant’s command. The dead humanoid retains its

the target is a Huge or larger object or creation of magical force, this ray disintegrates a 10-foot cube of it. Death Ray. The targeted creature must succeed on a DC 17 Dexterity saving throw or

Y'demi

Monsters Strixhaven: A Curriculum of Chaos

the target is a creature, it can’t regain hit points until the start of the Y’demi’s next turn. Blood Boil (Recharge 4–6);{"diceNotation":"1d6", "rollType":"recharge", "rollAction

blood mages almost impossible to ambush.NecroticSanguine Tentacles (1/Day). The blood in the copper basin disappears as tentacles of congealed blood fill a 10-foot cube centered at a point on the ground

Gigant

Monsters Bigby Presents: Glory of the Giants

30-foot cube. Each creature in that area must make a DC 19 Constitution saving throw, taking 45 (10d8);{"diceNotation":"10d8", "rollType":"damage", "rollAction":"Scale Dust", "rollDamageType":"poison

’t regain hit points.A gigant is a towering insectile creature variously regarded as a harbinger of doom, a defender of nature, and a divine messenger of mysterious purpose. Giants regard them as a

Moloch

Monsters Mordenkainen Presents: Monsters of the Multiverse

toward Moloch. Breath of Despair (Recharge 5-6);{"diceNotation":"1d6","rollType":"recharge","rollAction":"Breath of Despair"}. Moloch exhales in a 30-foot cube. Each creature in that area must

by this failure. He schemes of ways to reclaim his former status, but every time he enters the Nine Hells, he is demoted to an imp (see the Monster Manual) and can’t regain his normal powers

Eye and Hand of Vecna Legacy

Magic Items Dungeon Master’s Guide (2014)

both the hand and eye, you gain the following additional benefits: You are immune to disease and poison. Using the eye’s X-ray vision never causes you to suffer exhaustion. You experience

premonitions of danger and, unless you are incapacitated, can’t be surprise;surprised. If you start your turn with at least 1 hit point, you regain 1d10 hit points. If a creature has a skeleton

Potion of Vitality

Compendium - Sources->Dungeons & Dragons->Lost Mine of Phandelver

Potion of Vitality Drinking this potion removes any exhaustion you are suffering, cures any disease or poison affecting you, and maximizes the effect of any Hit Die you spend to regain hit points within the next 24 hours.

Drowned Ones

Compendium - Sources->Dungeons & Dragons->Ghosts of Saltmarsh

, the victim takes 18 (4d8) necrotic damage as the boils burst and spread. A creature reduced to 0 hit points by this damage cannot regain hit points until the disease is cured, though it can be stabilized as normal.

Drowned Ones BLUEROT This disease target humanoids. While afflicted with bluerot, a victim grows grotesque blue boils on their face and back. This disease is carried by undead (including the

Potion of Vitality

Compendium - Sources->Dungeons & Dragons->Basic Rules (2014)

Potion of Vitality Potion, very rare When you drink this potion, it removes any exhaustion you are suffering and cures any disease or poison affecting you. For the next 24 hours, you regain the

Potion of Vitality

Compendium - Sources->Dungeons & Dragons->Dungeon Master’s Guide (2014)

Potion of Vitality Potion, very rare When you drink this potion, it removes any exhaustion you are suffering and cures any disease or poison affecting you. For the next 24 hours, you regain the

Luba's Tarokka of Souls

Magic Items Tasha’s Cauldron of Everything

deck, you can use an action to cast one of the following spells (save DC 18) from it: comprehend languages, detect evil and good, detect magic, detect poison and disease, locate object, or scrying

, ability checks, and saving throws for the next hour. The deck can be used in this way twice, and you regain all expended uses at the next dawn. Prisoners of Fate. Whenever you use the Twist of Fate

Giant Rat

Compendium - Sources->Dungeons & Dragons->Monster Manual (2014)

Constitution saving throw or contract a disease. Until the disease is cured, the target can’t regain hit points except by magical means, and the target’s hit point maximum decreases by 3 (1d6) every 24 hours. If the target’s hit point maximum drops to 0 as a result of this disease, the target dies.

Swarms

Compendium - Sources->Dungeons & Dragons->Van Richten’s Guide to Ravenloft

vice versa, and the swarm can move through any opening large enough for a Tiny maggot. The swarm can’t regain hit points or gain temporary hit points. Actions Infestation. Melee Weapon Attack: +3 to

succeed on a DC 12 Constitution saving throw or contract a disease. Each time the diseased creature finishes a long rest, roll a d6 to determine the disease’s effect: 1–2. The creature is blinded

Blue Slaad

Compendium - Sources->Dungeons & Dragons->Monster Manual (2014)

phage. While infected, the target can’t regain hit points, and its hit point maximum is reduced by 10 (3d6) every 24 hours. If the disease reduces the target’s hit point maximum to 0, the target instantly

Blue Slaad The bone hooks that protrude from the back of a blue slaad’s hands inflict a terrible transformative disease on humanoids wounded by them. This infection, called chaos phage, transforms

Drowned Ascetic

Compendium - Sources->Dungeons & Dragons->Locathah Rising

disease. On a failed saving throw, the victim takes 18 (4d8) necrotic damage as the boils burst and spread. A creature reduced to 0 hit points by this damage cannot regain hit points until the disease is cured, though it can be stabilized as normal.

, the drowned ascetic must see the attacker. BLUEROT This disease target humanoids. While afflicted with bluerot, a victim grows grotesque blue boils on their face and back. This disease is carried

Cursed Villagers

Compendium - Sources->Dungeons & Dragons->Journeys through the Radiant Citadel

a disease but a curse. Sereno Sereno is a deadly magical affliction that inflicts a supernatural chill on its victims and eventually kills them. A creature cursed with sereno is poisoned, can’t regain

in sunlight. Sereno can be undone by magic that ends poison or disease, like lesser restoration, but only while the victim is in direct sunlight. Sereno is inflicted by an insidious, shapeshifting

D&D Beyond

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