Quote from Abelhawk >>

Quote from DIemortalscum >>

This spell might be one of the most powerful divination spells, even though it's a transmutation. 

Get 3 pitons and 1 ball of iron, then cast sequester on the ball and make the condition "when there is a  X  within  a one mile cube.

Next cast 3 sequesters on the pitons. make the condition "when the point of the piton is pointed at X "

Now you can fly all over the place and find whatever your looking for.

 That would be an extremely expensive use of this spell, since each casting costs 5,000 gp and ending it early would mean you'd have to reset it. It seems like it'd be more practical to use an array of magic mouths instead.

 Magic Mouth can only be tiggered by something within 30 feet of the object, and the trigger must be visual or auditory

Still, spending 20,000 gp on a shoddy arcane computer that costs at least 5,000 gp just to put a command into it is a pretty bad use of it. You may as well use scrying. I'm not even sure how the piton are supposed to work under that logic anyway, or how they work with the iron ball.

This spell is never used to its best. In the hands of powerful mages, it can be used to cast imprisonment on an ancient evil that returns every thousand years. Repeat that in the incredibly long gap between reappearances of said villain (There’s bound to be one level 17 wizard in 1000 years who’s willing to help), and that enemy will never reappear again. There’s just one flaw in this plan. Saving throws. But even that can be easily circumvented by creating numerous Sequesters. 

Quote from TheDm_God >>

This spell is never used to its best. In the hands of powerful mages, it can be used to cast imprisonment on an ancient evil that returns every thousand years. Repeat that in the incredibly long gap between reappearances of said villain (There’s bound to be one level 17 wizard in 1000 years who’s willing to help), and that enemy will never reappear again. There’s just one flaw in this plan. Saving throws. But even that can be easily circumvented by creating numerous Sequesters. 

The spell specifies that it has to be used on a willing creature.

Note: "You can set a condition". You don't have to do so in order for the Spell to work, it's just an option.

Has anyone thought of using sequester in tandem with spells like polymorph and enlarge/reduce?

My immediate thought is a LV.13 Simulacrum customizer. lol stay with me. Ofc it would take a lot of materials but assuming you have it, could you have 2 casters cast polymorph and/or enlarge/reduce on a creature, then sequester that creature in that state creating an “invisible statue”. My understanding of “time ceases to flow” is that their state or stats will not register the flow of time until the sequester is dispelled. Could a 13 lvl wizard then create a simulacrum from that creature in that state since simulacrum basically screenshots the creatures current stats and never changes or grows from there?