All d20 rolls that you are making, you're making with a disadvantage. (ability checks, attack rolls, etc)
However, all d20 rolls that affect you are also supposed to be made with a disadvantage. (attack rolls, stealth rolls against you, etc)
In addition to that, every time when you are trying to speak with any god, you accidentally being redirected to the god of misfortune. Therefore you can use any holy symbol as your holy symbol.