On a very simple level, the world is against your existence.
you take damage from holy water, holy weapons, and unholy weapons, as though you were an undead, fiend, or celestial. Whichever is least beneficial to you at the time.
Any turning ability of any cleric or paladin will affect you as though you were one of the normal applicable targets. (Destroy Undead does not work however)
Magical abilities that discern if you are lying or not always determine you to be lying.
The spells Detect Evil and Good, Protection from Evil and Good, Augury, Dispel Evil and Good, Hallow, Divine Word, Holy Aura and any other magical effect based on alignment or hostile intent takes full effect against you as though you were the intended target and/or enemy of the user of the spell/ability.
Any ability, such as Truesight, that attempts to determine your true form, sees you as the most dangerous creature the viewer can think of as your true form.
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