Your large hands make doing some things more difficult, while others get easier.
Dexterity Penalty: reduce dexterity by 1
Unarmed Melee Bonus: increase unarmed damage by 2
Monstrous Compendium Vol. 1: Spelljammer Creatures
Frozen Sick
D&D Beyond Basic Rules
Basic Rules (2014)
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Homebrew
Large Hands
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