This poison must be harvested from a dead or incapacitated blue-ringed octopus, and even then a single dose represents 1/20 of a single droplet diluted in 3 ounces of water. A creature subjected to this poison must make a DC 20 Constitution saving throw or becomes poisoned for 24 hours, and must repeat the saving throw at the start of each of its turns. On each successive failed save afterward, the creature experiences a new symptom.  A saving throw that fails by 5 or more is treated as 2 successive failures.  If the creature succeeds on a saving throw, it is cured of its most recent symptom, but retains all previous ones.  If the creature fails any saving throw by 10 or more, its heart stops and it dies.

• First Failure: The creature spends its actions each turn retching and reeling.
• Second Failure: The creature is blinded.
• Third Failure: The creature is paralyzed.
• Beyond Third Failure: The creature is unable to breathe (see the Suffocating entry in the “Environment” section in chapter 8 of the Player’s Handbook).

Contact. Contact poison can be smeared on an object and remains potent until it is touched or washed off. A creature that touches contact poison with exposed skin suffers its effects.

Ingested. A creature must swallow an entire dose of ingested poison to suffer its effects. The dose can be delivered in food or a liquid. You may decide that a partial dose has a reduced effect, such as allowing advantage on the saving throw or dealing only half damage on a failed save.

Inhaled. These poisons are powders or gases that take effect when inhaled. Blowing the powder or releasing the gas subjects creatures in a 5-foot cube to its effect. The resulting cloud dissipates immediately afterward. Holding one's breath is ineffective against inhaled poisons, as they affect nasal membranes, tear ducts, and other parts of the body.

Injury. Injury poison can be applied to weapons, ammunition, trap components, and other objects that deal piercing or slashing damage and remains potent until delivered through a wound or washed off. A creature that takes piercing or slashing damage from an object coated with the poison is exposed to its effects.