True Curse

You attempt to place a powerful curse onto a creature of your choice. The creature can be anywhere in existence, and is still a valid target for the spell. The targeted creature must succeed on a Wisdom saving throw or be cursed. What the curse will be is chosen by you when you cast the spell, choosing from the following options:

• You can replicate a spell of 7th level or lower that has the debuff tag. The chosen replicated spell targets only the creature targeted by this spell, and has an infinite duration unless the spell has a duration of instantaneous. You also don't need to meet any requirements of the spell, including costly components. The spell simply takes effect.
• You can inflict a poison you are familiar with onto the targeted creature.
• You can can inflict a disease you are familiar with onto the targeted creature.
• You can replicate the effects of a monster's regional effects, centered on the targeted creature, and with a range of 5 feet extending from the creature. These effects last until dispelled, and the creature cannot benefit from any positive effects from the regional effect. The DM has the final say on how the regional effect is implimented.
• You can choose an alternative curse effect, but it should be no more powerful than those described above. The DM has final say on such a curse's effect.

A remove curse spell only removes the effect if cast using an 8th level or higher spell slot. If cast with a lower level spell slot, the caster must roll 1d20 + the level spell slot used. If they roll an 18 or higher, the curse is removed.