Twist Form

This spell twists the physical form of a creature that you can see within range. An unwilling creature must make a Wisdom saving throw to avoid the effect. The spell has no effect on a shapechanger, a creature with 0 hit points, or entities without a solid form, such as ghosts, specters, wraiths, water, and water, air, or fire elementals. 

The transformation lasts for the duration, or until the target drops to 0 hit points or dies. On a failed save, choose one of the following options for the target to suffer.

• Limb Reversal
  • The target's hands and arms change place with their legs and feet. Any held equipment is dropped, though rings remain in place. All melee weapon attacks become unarmed strikes at disadvantage. Ranged weapon attacks can only be made with weapons that require one arm to use, and are made with disadvantage and without proficiency bonuses. Spell attacks with somatic components are made with disadvantage. Grapple attempts made against the target have advantage. 
• Joint Inversion
  • All the joints in a target's body invert direction. All forms of movement speed cannot exceed 10ft per round, barring magical enhancements. Melee and ranged weapon attacks are made with disadvantage. Grapple attempts made against the target have advantage. Strength and Dexterity checks made by the target have disadvantage. 
• Sense Restructuring
  •  The sensory organs of the target take up residence in new and inconvenient areas. If the target is wearing clothing, its eyes, nose, ears, and mouth migrate to areas covered by cloth. A clothed target is therefore blinded, and makes any hearing or smell based Perception checks with disadvantage. To be heard, or cast a spell with a Verbal component, a clothed target must make a Performance Check against your spellsave DC; it is unable to be heard on a failure.
     If a target does not have clothing, its sensory organs are migrated to inconvenient areas of its body. All checks made to perceive or investigate the environment are made with disadvantage, and take an entire action to complete (even if the statblock says they only take a bonus action).