Disjunction

A tiny transparent orb of pure magic appears in a space you can see within range and then expands into a 30-foot radius sphere. All spells and magical effects within the sphere are immediately ended. The sphere ignores resistance and immunity to magical affects.

Creatures. All creatures within the sphere when it appears must make an Intelligence saving throw or become disjoined from the Weave. A disjoined creature cannot cast or concentrate on spells, use spell like or magical abilities, or attune to magic items for 2d4 days. If a creature fails the save by 5 or more, the creature becomes permanently disjoined from the Weave. Only Wish or Divine Intervention can end the disjunction. Creatures within the sphere when it appears that are created, maintained, or summoned by magic are dispelled or banished to their original planes of existence.

Magic Items. Non-attuned magic items within the sphere when it appears become permanently disjoined, losing all magical properties. Attuned magic items are unaffected if the creature wearing or carrying them succeeds the save.

Artifacts. This spell can also be used as ritual lasting 1 hour to destroy an artifact with the DM's discretion The ritual might need to be completed in a special location, in the presence of a specific being, or with a very rare component that is difficult to obtain. Destroying an artifact has a 33 percent chance of permanently disjoining the spellcaster from the Weave and catch the attention of powerful beings associated with the artifact.