Curse Blood

You chose a creature within range and curses its blood. The creature must succeed in a Wisdom saving throw or it is affected by the curse. The target may chose fail the saving throw. When you cast this spell you chose one of the following curses options:

Infuse blood. You infuse the creatures blood with magic. Each time the cursed creature is attacked and takes bludgeoning, slashing or piercing damage the attacker also takes 1d10 necrotic damage, while necrotic energy bursts from the cursed creature's wounds. The attacked creature gain temporary hit points equals the number rolled in the d10. 

Intoxicate blood. You change the nature of the targeted creature, making its blood to become toxic to its own body. At the beginning of the cursed creature's turn, it takes 1d6 poison damage. The creature is also considered poisoned and have disadvantage on concentrations saving throws while the duration of the spell. 

Mark blood. You create a link with the cursed creature. For the next 24 hours you know the location of the creature while within 10 miles of you. You can communicate telepathically with it and know if the creature is being affected by any disease, poison or curse. When you curse a creature with this curse the spell ends but you keep having the link with the creature for the next 24 hours.

Change nature. You change the cursed creature's nature by changing its blood. For the duration you may chance the creature type for fiend, undead, beast or monstrosity. You also chose one ability and than chose for the creature have advantage or disadvantage in all rolls based in the chosen ability.  

If the cursed creature be target of a Greater Restoration or any similar spell, the spell ends. Remove Curse spell only removes the curse effect if cast using a 5th level spell slot or higher.