Base Class: Cleric
A Disease Domain cleric usually follows a nurturing deity (such as Helm, Pelor, or Psilofyr), or one with more malicious dominion over disease, poison, and infection (such as Talina, Incabulos, or Zuggtmoy). They tend to focus on supporting their congregation by petitioning their deity for protection from the plagues and contagions that they control or have the power to neutralize. But as with most things, the ability to cure can lead to the power to cause, and some clerics strive to spread disease across the land.
Scholar of Disease
When you choose this Domain at 1st level gain the Poison Spray Cantrip If you don’t already know it. It counts as a Cleric spell for you. Additionally you gain the Medicine skill and Herbalism tool proficiencies. You proficiency bonus is doubled for any ability check you make with either of those skills.
Channel Divinity: Flash Ward
Starting at 2nd level you can use your Channel Divinity to momentarily enhance a creature’s resistances. When a creature within 30 feet of you fails a saving throw you can use your reaction to have that creature reroll the saving throw with advantage, using the new result instead.
Blessed Resilience
At 6th level you become immune to disease and poison.
Potent Spellcasting
Starting at 8th level, you add your Wisdom modifier to the damage you deal with any cleric cantrip.
Radiant Symbiosis
Starting at 17th level you may use your action to activate an aura around you with a 30 foot radius that lasts for 1 minute, or you dismiss it with another action. Your enemies within the aura have disadvantage on all saving throws to resist poison or disease. Additionally each ally within the aura gains immunity to poison damage and the poisoned condition. After using this feature you cannot do so again until you finish a long rest.
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