I play in a group where the DM is perhaps a bit overly generous with loot and magic items and allows all WoTC content. She tries to balance that out with challenging encounters. Since Sylune's viper came along, our druid, who has a 22 Wisdom and a magic item that gives +2 to their spell attack and spell DC amongst other things, has locked down two bosses for the entire fight. These are the only two fights we have had since the spell was introduced. One was an Ancient Blue Dragon. Locked down and nova damaged in a couple rounds by our bladesinger and my paladin. Given the myriad ways of getting advantage in D&D 2024, relying on high AC to avoid the effects of Sylune's viper is not a very safe bet. The druid in my party also has a pretty high AC (23 I think), and a defensive spell from one of these Magic: the gathering 5e spin off setting books that can mitigate (and reflect) a fair bit of damage. They can also just recast Sylune's viper when the temp HP goes away. So the possibility of losing the Temp HP is not really much of an impediment (we are 12th level currently). Admittedly a small sample size and the power level of our party is a bit stupid, but the spell seems encounter breaking unless the enemy creature is immune to being poisoned or immune to magic. There should be a saving throw against the incapacitated condition, or the creature should become immune to that effect for a day or an hour after being subjected to it once.
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I play in a group where the DM is perhaps a bit overly generous with loot and magic items and allows all WoTC content. She tries to balance that out with challenging encounters. Since Sylune's viper came along, our druid, who has a 22 Wisdom and a magic item that gives +2 to their spell attack and spell DC amongst other things, has locked down two bosses for the entire fight. These are the only two fights we have had since the spell was introduced. One was an Ancient Blue Dragon. Locked down and nova damaged in a couple rounds by our bladesinger and my paladin. Given the myriad ways of getting advantage in D&D 2024, relying on high AC to avoid the effects of Sylune's viper is not a very safe bet. The druid in my party also has a pretty high AC (23 I think), and a defensive spell from one of these Magic: the gathering 5e spin off setting books that can mitigate (and reflect) a fair bit of damage. They can also just recast Sylune's viper when the temp HP goes away. So the possibility of losing the Temp HP is not really much of an impediment (we are 12th level currently). Admittedly a small sample size and the power level of our party is a bit stupid, but the spell seems encounter breaking unless the enemy creature is immune to being poisoned or immune to magic. There should be a saving throw against the incapacitated condition, or the creature should become immune to that effect for a day or an hour after being subjected to it once.