Either because you have spent most of your efforts performing the same work or you have a special favor or insight for the chosen specialty, you gain your proficiency bonus on daily checks (see Eureka!) in your specialty.

In order to attempt a breakthrough, you have to have a an alchemical recipe, a compound to start with, and/or parts, pieces, and fluids closely-related to what you are trying to achieve. No matter which, you need a fully stocked laboratory and at least 1 day per rarity level (Common = 1, Uncommon = 2, etc.) plus 1 day per spell level upon which the resulting compound is based. Each day requires raw materials costing 5gp, at least 8 hours of work, and an alchemical check with a DC equal to 10 + the day into the project using the better of your Medicine or Nature modifiers. Each success counts as progress towards your goal. On a failure, that entire day's work is unusable, wasting both time and money, but does not increase the DC day. If at any point; however, you have more failed days than successful ones, the entire project utterly fails, cannot be continued, and becomes useless. If the project ultimately proves successful, you produce one of the following results:

Duplication. You successfully copy a known compound, such as a potion, poison, dust or similar substance, providing enough for one use.
Enhancement. You successfully improve an existing compound, such as a Potion of Cure Wounds, increasing its efficacy one level, in this example to a Potion of Greater Cure Wounds. If level increase of the substance does not make any difference to the function of the substance, then you cannot choose this result.
Creation. You successfully create a known compound, such as a potion, poison, dust or similar substance, providing enough for one use. This substance is one of the lowest quality of its line, such as a Potion of Cure Wounds or a Potion of Hill Giant Strength.
Antidote. You successfully create an antidote for a specific poison, providing enough for one use. This cannot cure diseases, only poisons.
Medicine. This is one of the most difficult results to achieve. If you are working toward this goal, you must either have the assistance of a cleric or paladin or pass each daily check with a +2 on the DC. If you successfully create a medicine, you provide enough for one use (if a magical compound or instant cure for a disease) or 4d4+10 uses (if non-magical and doesn't instantly cure disease). This result might be Keoghtom’s ointment, an analgesic, antibiotic, antidepressant, antihistamine, cough syrup, diarrhea remedy, sedative, or other drug of similar level of function.

You have studied the ways and means of collapsing, shaping, and containing multi-dimensional objects to the exclusion of all other sciences. With this knowledge and your magical abilities (you must be able to cast at least 3rd level spells to attempt your feature below), you are able to perceive and create objects that others only wonder after.

Given a fully stocked laboratory and at least 3 days per rarity level (Common = 3, Uncommon = 6, etc.) plus 1 day per spell level upon which the resulting object is based, you may attempt to create various trans-dimensional wondrous items. Each day requires raw materials costing 5gp and at least 8 hours of work.  Every three days plus the final day requires an alchemical check with a DC equal to the item's base (see item list below) + 2 times the rarity of the item being attempted using your spellcasting ability modifier. Each success counts as progress towards your goal. On a failure, the last three day's are lost and unusable, wasting both time and money. If at any point, you have more failed attempts than successful ones, the entire project utterly fails, cannot be continued, and becomes useless. If the project ultimately proves successful, you produce one of the following pre-chosen results: