Absolutely! The monsters in the Monster manual and the races in the PHB are meant to be somewhat setting-independent so that you can fit them into a variety of homebrew worlds. As the DM, you are completely free to change, rework, reuse, or remove anything in your world.
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When I would make my own world, can I still use the monsters and races from the forgotten realms? (Monster Manual, Players Handbook)
Absolutely! The monsters in the Monster manual and the races in the PHB are meant to be somewhat setting-independent so that you can fit them into a variety of homebrew worlds. As the DM, you are completely free to change, rework, reuse, or remove anything in your world.