The only way to negate an item's magic properties is to put it in an antimagic field (or a dead magic zone, which is functionally the same thing except it's part of the environment.)
Older editions of D&D have a monster called an eater of magic. You could do-up a 5th edition monster of a similar sort by simply changing a few details on the rust monster so that it's not limited to affecting nonmagical equipment.
But, I have to second InquisitiveCoder's advice not to do this to your players - at least not without their foreknowledge and buy-in that such an outcome is a possibility. If you are wanting to remove an item from your game because it is having an effect that you didn't foresee before including it, the solution that is least likely to upset your players is to have an honest conversation about why you want the item gone.
I agree with the "discuss with your players" approach, and the advice not to unilaterally seize things from your players without warning, or story justification.
If you really must take away a high power item away that the players have grown accustomed to using, make it a ( semi ) voluntary giving up of the item, if you can.
Perhaps one of the party members is killed, and the high level Cleric demands the item as the price to revive their comrade. Even if it's not an item the Cleric would use, they could be seeking "true sacrifice as a sign of your commitment to your comrade".
Perhaps the item needs to be used/consumed/destroyed to stop "the big black evil about to pour through the dimensional gate and eat the sanctuary for lost puppies that is being run by Nuns".
Something like that takes the item away from the party, but gives them something of value in return: their fallen comrade or a great heroic accomplishment.
However, do not railroad them into a circumstance where they need to do that - don't go killing a party member just so that they must give up the item; they will justifiably feel strong-armed into it, and resent it.
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Does anyone have a idea of getting rid an item's magic enchantment. Like through a monster? A spell? An area?
Break the item.
I wouldn't recommend doing this to your players.
The Forum Infestation (TM)
How would I do this?
Why do you want to do that?
The only way to negate an item's magic properties is to put it in an antimagic field (or a dead magic zone, which is functionally the same thing except it's part of the environment.)
The Forum Infestation (TM)
Older editions of D&D have a monster called an eater of magic. You could do-up a 5th edition monster of a similar sort by simply changing a few details on the rust monster so that it's not limited to affecting nonmagical equipment.
But, I have to second InquisitiveCoder's advice not to do this to your players - at least not without their foreknowledge and buy-in that such an outcome is a possibility. If you are wanting to remove an item from your game because it is having an effect that you didn't foresee before including it, the solution that is least likely to upset your players is to have an honest conversation about why you want the item gone.
I agree with the "discuss with your players" approach, and the advice not to unilaterally seize things from your players without warning, or story justification.
If you really must take away a high power item away that the players have grown accustomed to using, make it a ( semi ) voluntary giving up of the item, if you can.
Perhaps one of the party members is killed, and the high level Cleric demands the item as the price to revive their comrade. Even if it's not an item the Cleric would use, they could be seeking "true sacrifice as a sign of your commitment to your comrade".
Perhaps the item needs to be used/consumed/destroyed to stop "the big black evil about to pour through the dimensional gate and eat the sanctuary for lost puppies that is being run by Nuns".
Something like that takes the item away from the party, but gives them something of value in return: their fallen comrade or a great heroic accomplishment.
However, do not railroad them into a circumstance where they need to do that - don't go killing a party member just so that they must give up the item; they will justifiably feel strong-armed into it, and resent it.
My DM Philosophy, as summed up by other people: https://drive.google.com/file/d/1rN5w4-azTq3Kbn0Yvk9nfqQhwQ1R5by1/view
Disclaimer: This signature is a badge of membership in the Forum Loudmouth Club. We are all friends. We are not attacking each other. We are engaging in spirited, friendly debate with one another. We may get snarky, but these are not attacks. Thank you for not reporting us.