The Cleric spell Contagion requires the victim to pass multiple saves before it ends.  That is, even if you pass the first save you are still poisoned, until you make a total of 3.

Does anyone know any other spells that do this?

Flesh to Stone

Flesh to stone is the opposite - you only make additional saves if you fail the first one.  For Contagion, you make more saves even if you roll a natural 20 on your first save.   But the caster does have to roll a to hit.

It's the closest there is.

If that's not acceptable then your answer is none.

I think there are some lair actions like this... I don't recall another spell... hmm... but what monsters was I looking at?

I imagine Contagion works the way it does because the disease effects it inflicts cannot be shaken without a curative action once they set in (no save to get over the disease), and they are all extremely debilitating, often outright crippling effects.  Even if the DM strikes Slimy Doom for being just outrageously, uncontrollably busted, any of the other diseases are no joke.  

Admittedly, the multisave thing renders the spell pointless in most combats, but it's a non-concentration crippling debuff.  Perhaps intended more as a tool for the DM than as a means for the players to be disease-spreading dickbats with.

I thought of it as incredibly useful.  Look, ignore the disease part, it is one of what, 2 spells that apply the 'poisoned' condition.  And Contagion does not require concentration.

The first level Ray of Sickenss requires a to hit and then poisons you for a single round, 

Contagion poisons you on a to hit and keeps you that way until you make 3 saves (or fail 3 saves, but that is worse than the poison).  Disadvantage on attacks and ability checks is significant.  Grapple that sucker and he is toast.

The only reason Contagion is not a great spell is the high level caused by the disease stuff. 

Scrap it out and simply have the spell make you stay poisoned and lose 1 hp a round  for 24 hours after failing 3 saves and you got a solid 3rd level spell.   I was hoping to find other spells similar to it - multiple saves to end the effect without requiring concentration.

Quote from Mog_Dracov >>

I thought of it as incredibly useful.  Look, ignore the disease part, it is one of what, 2 spells that apply the 'poisoned' condition.  And Contagion does not require concentration.

The first level Ray of Sickenss requires a to hit and then poisons you for a single round, 

Contagion poisons you on a to hit and keeps you that way until you make 3 saves (or fail 3 saves, but that is worse than the poison).  Disadvantage on attacks and ability checks is significant.  Grapple that sucker and he is toast.

The only reason Contagion is not a great spell is the high level caused by the disease stuff. 

Scrap it out and simply have the spell make you stay poisoned and lose 1 hp a round  for 24 hours after failing 3 saves and you got a solid 3rd level spell.   I was hoping to find other spells similar to it - multiple saves to end the effect without requiring concentration.

 I am *not* grappling someone with a disease you sick twisted man...

:)

Quote from Brewksy >>

Quote from Mog_Dracov >>

I thought of it as incredibly useful.  Look, ignore the disease part, it is one of what, 2 spells that apply the 'poisoned' condition.  And Contagion does not require concentration.

The first level Ray of Sickenss requires a to hit and then poisons you for a single round, 

Contagion poisons you on a to hit and keeps you that way until you make 3 saves (or fail 3 saves, but that is worse than the poison).  Disadvantage on attacks and ability checks is significant.  Grapple that sucker and he is toast.

The only reason Contagion is not a great spell is the high level caused by the disease stuff. 

Scrap it out and simply have the spell make you stay poisoned and lose 1 hp a round  for 24 hours after failing 3 saves and you got a solid 3rd level spell.   I was hoping to find other spells similar to it - multiple saves to end the effect without requiring concentration.

 I am *not* grappling someone with a disease you sick twisted man...

 

:)

 Papa Nurgle is disappointed in you

Though Lycanthropy doesn't work quite the same way, it has the same kind of ticking timer... you just don't get to make saves for it.  Your disease progresses through phases and if you're lucky someone removes the curse before it's too late and you take out the innocent village families that late summer moon... 

There's some monsters out there like Giant Subterranean Lizard with a multi round attack (grapple)->escape opportunity with DC->attack (swallow) progression that kinda sorta aproximates a similar effect? The save is optional and in the middle, and the saves on either end are actually monster attacks against AC... but at the end of the day, you still have a situation that is evolving over rounds after multiple checks. 

There are plenty of spells that require multiple saves. They all deal with status effects. You make a saving throw and if you fail you're affected by the condition and you make a saving throw at the end of each turn to drop the condition. For example Crown of Madness

It may not be exactly what OP asked about but it is worth noting that many spells and effects can trigger multiple saves in the form of concentration checks (which are con saves) that must be made even if the first saves are successful.  Magic missile, eldritch blast, scorching ray, and even multi-attack actions are all examples of single actions that can trigger multiple saves and hence the use of several legendary resistances. In practice these other examples aren't nearly as good as contagion at forcing the use of legendary saves since DC 10 con checks are easy for BBEGs and small batches of damage can be ignored much more easily than a debilitating disease, but they technically exist.